New GABA-Targeting Therapies for the Treatment of Seizures and Epilepsy: I. Role of GABA as a Modulator of Seizure Activity and Recently Approved Medications Acting on the GABA System.

The median percent reduction on seizure frequency from baseline was 61.5% in the ganaxolone group ( n = 10) and 24.0% in the placebo group ( n = 11), a difference that failed to reach statistical significance probably owing to the wide variation in intervals between seizure clusters [ 186 , 187 ].

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