Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Of the 245 UKB associations (226 previously reported + 19 previously unreported associations), we find that 72% (176) show at least nominally significant ( p < 0.05 ) age-specific effects within UK women ( Figure 2 C). 37 of these 176 associations, representing 15% of all associations, have a slope with a genome-wide significant p value ( p < 5 × 10 − 8 ), constituting a more stringent criterion (strong and moderate evidence in Figure 2C).

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