Validation and optimization of AFP-based biomarker panels for early HCC detection in Latin America and Europe.

Interestingly, ASAP was able to discriminate cirrhosis from both early-stage and advanced-stage pre-HCC (Figure 3 A, p < 0.0001 for both comparisons), while GALAD only showed a trend for discriminating cirrhosis from advanced-stage pre-HCC ( p > 0.05) (Figure 3 B).

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