Multiple genes in a single GWAS risk locus synergistically mediate aberrant synaptic development and function in human neurons.

Cell Genom · 2023 · PMC10504676 · PMID 37719141

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0500

boldest claim

The sentences

highly significantp = 1.4 × 10 −5actually significant

The gene × gene interaction terms were highly significant, with VPS45 _KD × C1orf54 _KD ( β = 0.26, p = 1.4 × 10 −5 ) and VPS45_ KD × lncRNA _KD ( β = 0.16, p = 6.7 × 10 −5 ) positively correlated with the SNP editing effect ( Figure 6 J).

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nominally significantp < 0.05actually significant

Of the 17 SZ loci with genome-wide significant (GWS) risk SNPs showing ASoC in iN-Glut, 13 9 had a nominally significant difference of ASoC (p < 0.05) in NGN2-Glut.

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