Characterization of RNA driven structural changes in full length RIG-I leading to its agonism or antagonism.

Nucleic Acids Res · 2023 · PMC10516622 · PMID 37486777

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a clear trendno p-value reported

Finally, a clear trend was observed for both pairs of 5′-OH and 5′-ppp RNAs between their affinity for FL RIG-I and the extend to which they can stimulate the IFN pathway, confirming that for analyzed RNAs, the presence of 5′-ppp RNA modification is correlated with RIG-I’s enhanced ability to signal (Tables 1 and 2 ).

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