The differences in the antibody titers induced through the different DNA- and protein-based vaccines did not reach statistical significance, although recombinant proteins showed a pronounced trend to induce higher antibody titers than vector DNAs at the dosages used here ( Figure 3A ).
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Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice.
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The sentences
The differences in the antibody titers induced through the different DNA- and protein-based vaccines did not reach statistical significance, although recombinant proteins showed a pronounced trend to induce higher antibody titers than vector DNAs at the dosages used here ( Figure 3A ).