Effect of Fenofibrate on Ethanol-Induced Microglial Reactivity Regarding microglia reactivity, while not reaching statistical significance, fenofibrate showed a trend towards doubling the number of cells displaying an anti-inflammatory morphology (M2) in comparison to the vehicle group ( Figure 4 ) (fenofibrate vs. vehicle: 1633 ± 375 vs. 823 ± 234, ANOVA F (3,86) = 1.76; p = 0.16).
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Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism.
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