The Impact of Drug-Drug Interactions on the Toxicity Profile of Combined Treatment with BRAF and MEK Inhibitors in Patients with BRAF-Mutated Metastatic Melanoma.

Cancers (Basel) · 2023 · PMC10526382 · PMID 37760556

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hedged sentences

0.0680

closest p · 1.4× alpha

0.0680

boldest claim

The sentences

a trend toward significancep = 0.068so close (0.05 < p ≤ 0.1)

high-grade DDIs had better outcomes in terms of OS ( p = 0.0012) and a trend toward significance in PFS ( p = 0.068).

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did not reach statistical significanceno p-value reported

At the same time, the improvements in survival outcomes did not reach statistical significance when BRAF/MEK association was compared to E monotherapy [ 28 ].

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