Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.

J Allergy Clin Immunol · 2023 · PMC10529397 · PMID 37004747

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The father’s memory CD45R0 + CD4 + T cells showed a trend and P1’s memory CD4 + T cells a distinctly augmented proportion of H2Ax phosphorylation after in vitro treatment of PBMCs with the DSB inducing drug bleomycin sulfate 70 ( Fig 5 , D ).

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