Regulation of Transporters for Organic Cations by High Glucose.

Int J Mol Sci · 2023 · PMC10531077 · PMID 37762353

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an apparent trendno p-value reported

Interestingly, an apparent trend towards higher hOCT2 mRNA expression was observed in kidneys from diabetic patients, a pathology characterized by high serum glucose levels.

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did not reach statistical significanceno p-value reported

Nevertheless, it is important to highlight that the K m for ASP + uptake in hOCT1-HEK293 cells exhibits a twofold increase after 48 h of incubation with 16.7 mM glucose compared to what was observed under 5.6 mM glucose conditions, even though this difference did not reach statistical significance.

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