A Decrease in Maternal Iron Levels Is the Predominant Factor Suppressing Hepcidin during Pregnancy in Mice.

Likewise, the hepatic expression of SMAD family member 7 ( Smad7 ), a downstream target of BMP signaling was also decreased at both E12.5 and E18.5 when compared to nonpregnant mice, although the decrease in non-iron-loaded pregnant mice at E18.5 did not reach statistical significance ( Figure 1 D).

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