In Systemic Sclerosis Patients, Peripheral Blood CD21<sup>low</sup> B Cells and Serum IL-4 and IL-21 Influence Joint Involvement.

Peripheral Blood CD21 low B Cells and Serum IL-4 and IL-21 Levels We found a slightly significant positive linear correlation between the percentage of peripheral blood CD21 low B cells and the serum IL-4 level (r = 0.315; p < 0.05) ( Figure 1 a) and serum IL-21 level (r = 0.351; p < 0.01) ( Figure 1 b).

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