Prevalence and Predictors of Nonadherence to Direct Oral Anticoagulant Treatment in Patients with Atrial Fibrillation.

with this arrhythmia. 1 This is because DOACs, compared to VKA targeted at an international normalized ratio of 2.0 to 3.0, were are at least as effective and had a better safety profile. 2 3 4 5 In a meta-analysis, DOACs reduced the endpoint of stroke or systemic embolism by 19%, showed a strong trend toward fewer major bleedings, and mortality was significantly lower as compared to VKAs. 6 Moreover, DOACs have an improved ease of use due to the fixed dosing regimen, obviating the need for routine laboratory monitoring.

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