Time-dependent memory transformation in hippocampus and neocortex is semantic in nature.

Analyzing the anterior-posterior hippocampal representational similarity between items at encoding and their corresponding semantically related lures by means of an LMM, the posterior hippocampus tended to show a higher reinstatement of the semantic gist of the original memory compared to the anterior hippocampus, which, however, failed to reach statistical significance (main effect long axis: t (6124) = 1.94, p = 0.052, β = 0.004, 95% Confidence Interval = [–4 e –05, 0.01]; see Supplementary Fig. 6 ).

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