Enhanced IL-17 Producing and Maintained Cytolytic Effector Functions of Gut Mucosal CD161⁺CD8⁺ T Cells in SIV-Infected Rhesus Macaques.

Frequencies of cells expressing Granzyme B were significantly lower in CD161 + CD4 + T cells of PBMC ( p = 0.002), and colon ( p = 0.0108), and showed a trend of reduction in BAL ( p = 0.0519), suggesting the impaired cytolytic potential across immune compartments, including peripheral blood, gut, and airway ( Figure 8 A).

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