In anti-CD20-treated pwMS, there was only a declining trend in antibody titers until six months after primary vaccination that did not reach statistical significance, but booster vaccination also led to significantly higher titers compared to primary vaccination.
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Long-Term Immune Response Profiles to SARS-CoV-2 Vaccination and Infection in People with Multiple Sclerosis on Anti-CD20 Therapy.
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T-cell response presented a decreasing trend after primary and booster vaccination in both groups; however, this was not statistically significant ( Figure 5 B,C).