Polygenic risk scores of lithium response and treatment resistance in major depressive disorder.

Transl Psychiatry · 2023 · PMC10539379 · PMID 37770441

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a clear trendno p-value reported

To further quantify the effect of a polygenic load of lithium response among MDD, we divided the MDD cases into quartiles based on their PRS of lithium response and observed a clear trend of a higher proportion of TRD cases in the higher PRS quartiles ( P trend < 0.005 in all definitions; Fig. 1C ).

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