Real-world data emulating randomized controlled trials of non-vitamin K antagonist oral anticoagulants in patients with venous thromboembolism.

BMC Med · 2023 · PMC10542685 · PMID 37775786

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did not reach statistical significanceno p-value reported

While AMPLIFY (RR 0.31, 95% CI 0.17–0.55) and EINSTEIN-PE (HR 0.49, 95% CI 0.31–0.79) trials found a significantly lower risk of major bleeding, the results of the corresponding emulations showed the same direction but did not reach statistical significance.

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