Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants.

Brain · 2023 · PMC10545504 · PMID 37284795

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highly significantno p-value reported

Neurophysiological parameters show highly significant differences between sexes: the mean conduction velocities in ulnar (35.8 ± 6.4 versus 47.8 ± 6.4 m/s) and median (34.1 ± 7.3 versus 42.8 ± 8.8 m/s) motor nerves are markedly slower in males, and the corresponding mean CMAP amplitudes in ulnar (4.0 ± 2.9 versus 6.4 ± 2.4 mV) and median (2.6 ± 2.8 ve

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a clear trendno p-value reported

When examined by sex, the magnitudes of change in CMTES from baseline rarely reach statistical significance, but there is a clear trend to disease progression.

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