In terms of bleeding risk, the pooled analysis showed no significant difference but it should be noted that the AXADIA-AFNET 8 and VALKYRIE trials showed a trend towards less major bleeding while the RENAL-AF trial showed a trend towards increased risk of bleeding.
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The safety and efficacy of direct oral anticoagulants among chronic kidney disease patients on dialysis with non-valvular atrial fibrillation: a meta-analysis.
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