Reductions in percentage of heavy drinking days, the primary outcome, were significantly lower for psilocybin compared to diphenhydramine and reductions in percentage of drinking days favored psilocybin but only approached significance ( p = 0.05).
Visual inspection of plots comparing cardiovascular and anxiety measures for Week 3 versus Week 7 psilocybin sessions among participants in the Standard group who were randomized to no Visual Healing video during the Week 3 psilocybin session and went on to choose to watch or not watch the video in Week 7 suggest a possible trend towards lower blood pressure and higher heart rate in Week 7 overall but the small number of participants and lack of random assignment to the video precludes making any conclusions regarding the role of choosing the video in Week 7.