Fentanyl-induced reward seeking is sex and dose dependent and is prevented by D-cysteine ethylester.

Front Pharmacol · 2023 · PMC10546209 · PMID 37795030

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a negative trendno p-value reported

Male rats pretreated with 10 mg/kg D-CYSee (L-D-CYSee) 15-min prior to conditioning with 5 μg/kg fentanyl did not show a significant change in CPP from 5 μg/kg fentanyl-treated controls ( p = 0.159) although a negative trend in CPP was observed.

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a positive trendno p-value reported

No significant difference in preference was found between 0.5 μg/kg fentanyl and the saline control group ( p = 0.067), although a positive trend in preference was observed.

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