a strong trendP = 0.0510
Additionally, we found mediating effects of C-C motif chemokine ligand 13 (CCL13) and endothelial monocyte-activating polypeptide II (EMAP-II) between OSA and HBP with the IVW-RE method; however, in the cML-MA-BIC method, the negative association between OSA and EMAP-II only showed a strong trend of statistical significance ( P = 0.0510), and the negative association between OSA and CCL13 approached statistical significance ( P = 0.0668).