Cold Case of Thrombolysis: Cold Recombinant Tissue Plasminogen Activator Confers Enhanced Neuroprotection in Experimental Stroke.

19 Moreover, the hypothermia group's modified Rankin scale scores displayed a positive trend of improvement at 3 months. 18 In parallel, intravascular hypothermia improved the neurological scores of stroke patients who received intravenous thrombolysis. 20 Selective hypothermia therapy, as an adjunct to thrombolysis, appears effective when the target temperature reduction encompasses immediately the ischemic penumbra after the stroke onset.

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24 Clinical trials revealed that point estimates correspond to a benefit of alteplase treatment within the range of 35.5 °C to 37.5 °C but showed a negative trend >37.5 °C.

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