Value of faecal exfoliated cells in colorectal tumour screening using SDC2 methylation test.

Accumulated evidence shows that epigenetic gene regulation is closely related to tumourigenesis, and it has been reported that the positive detection rate of the mSDC2 test in different age groups ranged from 2.2% to 29.7%, and showed a trend for increasing relationship between the methylation rate of the SDC2 gene and the PPV value for CRC, especially in the population above 50 years of age.

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Therefore, PPV showed an increasing trend with age in all groups except the AA and AD groups, and the PPV of the SDC2 methylation test for colorectal tumours showed an increasing trend. 3.6. mSDC2 methylation levels among different pathological types The cycle threshold (CT) of the mSDC2 test was different between the groups (see Figure 2 ), with the CT of mSDC2 in normal patients at (46.74 ± 5.36), in polyp-­detected patients at (41.03 ± 5.26), in AD-detected patients at (42.42 ± 5.23), in AA-detected patients at (37.36 ± 5.58) and in CRC-detected patients at (34.35 ± 4.98).

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