TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content.

Front Immunol · 2023 · PMC10551148 · PMID 37809073

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did not reach statistical significanceno p-value reported

Regarding M1 macrophages, although upon TRAIL treatment there was a slight increase in the expression of the M1 markers CXCL10, CXCL11, and IDO1, and a slight decrease in the expression of the M2 markers TMEM37 and ANGPTL4, this did not reach statistical significance ( Table S1B ).

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