Dual Immune Checkpoint Blockade Induces Analogous Alterations in the Dysfunctional CD8+ T-cell and Activated Treg Compartment.

In contrast, nonresponding tumors showed a trend toward an increased expression in activation and dysfunction signatures upon treatment in some T-cell subsets, along with an increase in the expression of inhibitory receptors PDCD1 , CTLA4 , and LAG3 across different T-cell subsets.

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