Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury.

Moreover, the intracortical injection of the control IgG1 or rCD300f-IgG1 into CD300f −/− mice showed a strong trend towards increasing the lesion volume when compared to WT mice injected with control IgGs (40 ± 4% increased lesioned hemisphere, p = 0.072 or 40 ± 3% increased lesioned hemisphere, p = 0.052 respectively) (Fig. 4 C), suggesting that the absence of CD300f is neurotoxic after a penetrating brain injury.

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