Epigenomic signature of major congenital heart defects in newborns with Down syndrome.

Hum Genomics · 2023 · PMC10559462 · PMID 37803336

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There were 1588 nominally significant ( p < 0.05) differentially methylated regions (DMRs) (35% hypermethylated, 65% hypomethylated) distinguishing DS-CHD from DS non-CHD, and these regions were enriched for terms related to the heart, as well as neurodevelopment and metabolism [ 16 ].

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