Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.

BCT‐100 caused a time‐dependent increase in ASS1 levels (Fig EV3C ), while this was partially reduced in the presence of imatinib, although this did not reach statistical significance (Fig EV3D ).

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While the changes here failed to reach significance following multivariate analysis (Fig EV3H ), when examining L‐arginine levels, we confirmed a consistent decrease in both normal and CML datasets (Fig EV3I ).

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While the percentage of human CD45 + cells was variable (Fig EV5D ), there was a decreasing trend in percentage and absolute number of CD45 + CD34 + cells in BCT‐100‐treated mice, with no significant difference between BCT‐100 and combo‐treated mice (Fig EV5E and F ).

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