Single cell variability of CRISPR-Cas interference and adaptation.

The primed interference phase showed a trend similar to direct interference: a broadening of the PLT distribution yielding a slow‐down on average (Fig 6B ).

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Upon induction, some lineages showed a decreasing trend in fluorescence as early as 4 h (Fig 2E and F , Expanded view Movie EV2 ), while others remained fluorescent after 35 h (Fig 2F ).

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