Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine.

NPJ Vaccines · 2023 · PMC10562438 · PMID 37813912

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a significant trendno p-value reported

The particle sizes of lactose, mannitol, glucose, and trehalose showed a significant trend compared to before lyophilization, but the particle size of sucrose was increased by approximately 20 nm.

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