The Rho GTPase exchange factor Vav2 promotes extensive age-dependent rewiring of the hair follicle stem cell transcriptome.

This phenomenon is quite significant for the Vav2 Onc/Onc waves at: 1) [+0.6], which also contains transcripts present in the WT waves [–1], [+0.6], [+0.6+1], [–1–4] and [+1]; 2) [+1], with transcripts present in the WT waves [+1], [+0.6+1], [–6], and [–12]; 3) [+1+6], with transcripts present in the WT waves [+0.6], [–1], [–1–4] [–12], and [–1–12]; and 4) [–1–12], with transcripts present in the WT waves [+1+2.5+6], [+2.5 +6], [+6+2.5], [–0.6–12], [–1], and [–12] ( Figure 3 ).

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