Barely Significant
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Relationship between gut microbiota and thyroid function: a two-sample Mendelian randomization study.

Front Endocrinol (Lausanne) · 2023 · PMC10562735 · PMID 37822602

Europe PMCDOI
1
hedged sentence
0.0488
closest p · 1.0× alpha
0.0488
boldest claim

The sentences

nominally significantP =0.0488actually significant
However, there were two nominally significant causal relationships that hyperthyroidism was associated with an increased risk of order MollicutesRF9 (id.11579) (OR=1.067, 95% CI: 1.0003-1.138, P =0.0488), while hypothyroidism was associated with an increased risk of genus Ruminococcaceae UCG005 (OR=1.038, 95% CI: 1.001-1.078, P =0.0497). 4 Discussion This study comprehensively assessed the causal effects of 211 taxonomic groups within the domain of Genus and Species (from phylum to genus levels) on thyroid function, encompassing parameters such as FT4, TSH, hypothyroidism, and hyperthyroidism.

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