Barely Significant
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Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis.

Blood Adv · 2023 · PMC10562769 · PMID 37267439

Europe PMCDOI
2
hedged sentences
0.0890
closest p · 1.8× alpha
0.0890
boldest claim

The sentences

did not achieve significanceP = .089so close (0.05 < p ≤ 0.1)
In the intermediate-age cohort, NPM1 mut / IDH mut patients had improved OS compared with NPM1 mut / IDH WT (62.5% [95% CI, 43.5-76.8] vs 38.2% [95% CI, 29.3-47.0]; P = .009), but EFS differences did not achieve significance for NPM1 mut / IDH mut vs NPM1 mut / IDH WT (41.5% [95% CI, 26.0-56.4] vs 27.4% [95% CI, 19.7-35.6]; P = .089) ( supplemental Figure 1 ).

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did not reach statistical significanceno p-value reported
Pediatric and AYA patients with IDH mut / NPM1 mut / FLT3 -ITD AML experienced inferior OS compared with those with IDH mut / NPM1 mut / FLT3 -non-ITD, although these differences did not reach statistical significance.

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