Proteomic Analysis Reveals the Neurotoxic Effects of Chronic Methamphetamine Self-Administration-Induced Cognitive Impairments and the Role of Melatonin-Enhanced Restorative Process during Methamphetamine Withdrawal.

J Proteome Res · 2023 · PMC10563163 · PMID 37676068

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

did not reach statistical significanceno p-value reported

Additionally, some mitochondrial-related proteins did not reach statistical significance but showed a high change in their expression, more than 2-fold when compared between METH and control.

also in 111,027 other papers

an increasing trendno p-value reported

The following proteins that show a 2-fold decreasing trend were Park7, Vps35, Snca, and Mtco2. In contrast, some proteins expressed at low levels in METH-WD mice showed an increasing trend after melatonin treatment, for instance, Syn1, Syp, Ndufb4, and Cox6c.

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.