Identification and analysis of individuals who deviate from their genetically-predicted phenotype.

These results were nominally significant ( P < 0.05) when limiting our analysis to 3 genes in which variants have previously been described as causal for some of the most prevalent syndromes associated with tall stature, specifically Marfan syndrome ( FBN1 ) [ 6 – 8 ], Weaver syndrome ( EZH2 ) [ 9 ], and Sotos syndrome ( NDS1 ) [ 10 ] (OR = 43.7 [95% CI 1.06, 271], P = 0.024).

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