GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes.

Although the absolute energy expenditure values were unchanged between genotypes ( Figure 1P and Figure 1—figure supplement 1I ), ANCOVA revealed a leftward shift in the relationship between body weight and energy expenditure in OPA1 BKO mice with a nearly significant group effect (p=0.055) ( Figure 1Q ).

also in 3,349 other papers