Rare variant associations with plasma protein levels in the UK Biobank.

For example, there were significant associations between PTVs in PSAP and increased progranulin ( GRN ; P = 5.5 × 10 −17 ; β = 2.60; 95% CI, 1.99 to 3.21) and cathepsin B ( P = 1.2 × 10 −11 ; β = 2.10; 95% CI, 1.49 to 2.70), and a nearly significant association with increased cathepsin D ( P = 9.0 × 10 −8 ; β = 1.61; 95% CI, 1.02 to 2.20) (Supplementary Table 8 ).

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