Comprehensive profiling of neutralizing polyclonal sera targeting coxsackievirus B3.

Nat Commun · 2023 · PMC10570382 · PMID 37828013

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closest p · 1.6× alpha

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did not reach statistical significancep = 0.08so close (0.05 < p ≤ 0.1)

Overall, mutants conferring escape from multiple sera (>20% of the sera tested) had strong fitness costs (average fitness of 0.28 ± 0.11), while those conferring escape from only a few sera (<20% of the sera tested) were less deleterious (average fitness of 0.73 ± 0.35), although this difference did not reach statistical significance ( p = 0.08 by a two-tail t-test).

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