CRISPR deletion of a SINE-VNTR-<i>Alu</i> (SVA_67) retrotransposon demonstrates its ability to differentially modulate gene expression at the <i>MAPT</i> locus.

Front Neurol · 2023 · PMC10570551 · PMID 37840928

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0.0999

closest p · 2.0× alpha

0.0999

boldest claim

The sentences

did not reach statistical significancep = 0.0999so close (0.05 < p ≤ 0.1)

In addition, a 50% increase in KANSL1 gene expression correlated with the SVA_67 CRISPR edit cell lines compared to controls, however this did not reach statistical significance ( p = 0.0999).

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