OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation.

It is interesting to note that in the IL10 deficiency model (spontaneous colitis) the pro-inflammatory effects of TDAG8 deficiency became clearly visible and highly significant.

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The Absence of Ogr1 Reduces Pro-Inflammatory Cytokine Expression in Tdag8-Deficient mice in the Model of Spontaneous Colitis Transcriptional analysis showed a trend towards a decreased expression of Tnf and Il-6 in Il-10 −/− × Ogr1 −/− mice when compared with Il-10 −/− mice ( Figure 5 A,B).

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