Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis.

At baseline, single Tnfr1 −/− and single Tnfr2 −/− organoids showed a trend toward increased lumen size compared with Tnfr1 −/− Tnfr2 −/− double-knockout organoids without treatment, which suggests that TNFR1 and TNFR2 each partially contribute to lumen size during homeostasis.

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