Leptin-mediated meta-inflammation may provide survival benefit in patients receiving maintenance immunotherapy for extensive-stage small cell lung cancer (ES-SCLC).

Cancer Immunol Immunother · 2023 · PMC10576666 · PMID 37668709

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.2700

boldest claim

The sentences

a strong trend toward significancep = 0.07so close (0.05 < p ≤ 0.1)

Similary, a strong trend toward significance was observerd for OS (18.04 vs 12.09 mo; HR: 0.53 [0.25–1.29] p = 0.07) (Fig. 4 ).

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borderline significancep = 0.07so close (0.05 < p ≤ 0.1)

Cluster A was strongly associated with better PFS ( p = 0.01) but, again, only a borderline significance was reached for OS ( p = 0.07), probably due to small sample size.

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a positive trendp = 0.27not close (p > 0.1)

Regarding to OS analysis, absence of liver metastases confirmed to be associated with better outcomes ( p = 0.0002); conversely, “high” leptin/VAT ratio did not reached stastical significance, despite a positive trend toward association was still confirmed ( p = 0.27), considering the early follow-up evalutation (Table 2 ).

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