Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

We did not find any significant associations after adjusting for the 489 allele/outcome combinations tested ( Figure 3 ; Table S6 ) and did not find any nominally significant associations with any of the major risk HLA alleles for the four indications, with the HLA-Cw6 (C ∗ 06) allele previously associated with response to anti-IL17 therapy 26 or with the HLA-DQA1 ∗ 05 alleles previously associated with TNFi immunogenicity 14 , 15 , 16 ( Table S4 ).

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