Defective phagocytosis leads to neurodegeneration through systemic increased innate immune signaling.

Simultaneous knockdown of drpr and Relish in glia also led to reduced vacuolization compared to drpr knockdown alone, although the effect did not reach statistical significance with a small sample size ( Figure S4 ).

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The percentage of GFP-positive pericerebral fat body was quantified in several sections per head, and we found a highly significant increase in AttA expression in aged, but not young, drpr mutants, compared to age-matched controls ( Figure 3 G).

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While AttD expression showed an increasing trend as drpr Δ5 flies aged, this change was not significant ( Figure 1 B).

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