Influence of autozygosity on common disease risk across the phenotypic spectrum.

We additionally refitted the regressions in the highly consanguineous UKB EUR and UKB SAS cohorts for the significant phenotypes, adding the confounders assessed in Table S1 as covariates, and found no reduction in effect size magnitude; the ratio of the effect size from regression with the additional covariates and the original regressions was 1.05 in UKB SAS and 1.10 in UKB EUR (p = 0.73 and p = 0.47, respectively, paired t test), and no phenotype had a nominally significant difference in the effect size estimates ascertained from the two regressions ( Table S4 ).

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We note that although these trends are highly significant, the changes are relatively modest; for example, 23% of British Pakistani individuals aged 70–80 years were inferred to be offspring of first cousins or closer, compared with 38% of those aged 15–30 years ( Figure S1 ).

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