Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity.

Acta Neuropathol Commun · 2023 · PMC10580588 · PMID 37845749

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0.0890

closest p · 1.8× alpha

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boldest claim

The sentences

a strong trendP = 0.089so close (0.05 < p ≤ 0.1)

Upon calculation of the percent fluorescence recovery for the entirety of the experiment however, we documented a significant decrease in the recovery rate for SETX KO iPSC-MNs, but only observed a decrease in the recovery rate for SETX L389S iPSC-MNs, which constituted a strong trend ( P = 0.089) (Fig. 8 c).

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