Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion.

Our studies were not designed to evaluate metabolic effects, but we noticed that, despite similar food intake, Smlr1 −LKO mice had reduced fat mass (Figure S8 B,C) and showed a trend toward reduced body weight gain (Figure 6 B).

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