There was a clear trend for CoxIV expression to be higher in cytokine-expressing CD8 + T and CD4 + T cells than in cytokine-negative populations ( Figure 2 E; supplemental Figure 2 D), supporting a relationship between mitochondrial mass and effector function.
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Uptake of long-chain fatty acids from the bone marrow suppresses CD8+ T-cell metabolism and function in multiple myeloma.
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The sentences
When all patient samples were combined, this difference was highly significant ( Figure 1 E; supplemental Figure 1 H).